Brian Blessed as Aeneas Sylvius Piccolomin

James Faulkner as Cardinal Guillaume D'Estouteville

Rolf Kanies as Cardinal Bessarion

Manu Fullola as Rodrigo Borgia

Dominic Boeer as Orsinis Ritter

Nora Tschirner as Vanozza

Holger Kunkel as Cardinal Alain D'Avignon

Nicholas Irons as Prospero Colonna

Brian Downey as Cardinal Juan De Mella

Lolo Herrero as Pedro Luis Borgia

Gaetano Carotenuto as Captain Gaetono

Matthias Koeberlin as Guiliano Della Rovere

Joseph Rutten as Pope Calixtus III

Andrew Keilty as Young Priest

Stacy Smith as Pantasilia

Lee J. Campbell as Chancellery Official

Richard Donat as Cardinal Pietro Barbo

Lex Gigeroff as Cardinal Isidore

John Dunsworth as Cardinal Calandrini

John Dartt as Physician in Ostia

Jeremy Webb as Orsini Swordsman