Audrey Tautou as Amélie Poulain

Mathieu Kassovitz as Nino Quincampoix

Rufus as Raphaël Poulain

Serge Merlin as Raymond Dufayel

Jamel Debbouze as Lucien

Clotilde Mollet as Gina

Claire Maurier as Suzanne

Isabelle Nanty as Georgette

Dominique Pinon as Joseph

Artus de Penguern as Hipolito

Yolande Moreau as Madeleine Wallace

Urbain Cancelier as Collignon

Lorella Cravotta as Amandine Poulain

Maurice Bénichou as Dominique Bretodeau

Michel Robin as Mr. Collignon

Andrée Damant as Mrs. Collignon

Claude Perron as Eva

Armelle as Philomène

Ticky Holgado as Man in Photo

André Dussollier as Narrator (voice)

Eugène Berthier as Eugène Koler

Charles-Roger Bour as Man with Pissoir

Kevin Dias as Young Dominique

Flora Guiet as Young Amélie

Amaury Babault as Young Nino

Marion Pressburger as Small Hands

Luc Palun as Amandine's Grocer

Fabienne Chaudat as Woman in Coma

Dominique Bettenfeld as Amélie's Neighbor

Jacques Viala as Client Humiliating Friend

Fabien Béhar as Humiliated Friend

Jonathan Joss as Humiliated Friend's Son

Jean-Pierre Becker as Homeless Man

Jean Darie as Blind Man

Thierry Gibault as Endive Client

François Bercovici as Endive Client's Friend

Franck Monier as Young Dominique

Guillaume Viry as SDF

Valérie Zarrouk as Dominique's Wife

Marie-Laure Descoureaux as Concierge of the Dead

Sophie Tellier as Aunt Josette

Gérald Weingand as Teacher

François Viaur as Bistro Owner

Paule Daré as Bistro Employee

Marc Amyot as Unknown at Photo Booth

Myriam Labbé as Tobacco Store Costumer

Jean Rupert as Operated on the Nasal Septa

Frankie Pain as Newspaper Seller

Julianna Kovacs as Grocery Customer

Philippe Paimblanc as Train Controller

Mady Malroux as Twin #1

Monette Malroux as Twin #2

Robert Gendreu as Café Customer

Valériane de Villeneuve as Laughing Woman

Isis Peyrade as Samantha

Raymonde Heudeline as Ghost Train Cashier

Christiane Bopp as Woman Near Merry-Go-Round

Thierry Arfeuillères as Man Statue

Jerry Lucas as Little Boy of Sacré-Coeur

Patrick Paroux as Street Blower

François Aubineau as Concierge's Postman

Philippe Beautier as Poulain's Postman

Karine Asure as Pretty Girl

Régis Iacono as Félix L'Herbier

Franck-Olivier Bonnet as Palace Video (voice)

Alain Floret as Concierge's Husband (voice)

Jean-Pol Brissart as Jacques Grosjean (voice)

Frédéric Mitterrand as Frédéric Mitterrand (voice)

Laurent Delpit as Montmartre Man (uncredited)

Manoush as Nymphomaniac (uncredited)

Jacques Thébault as (voice) (uncredited)

Dean Baykan as (uncredited)

Clément Chebli as (uncredited)

Eloïse Labro as (uncredited)