Ioan Gruffudd as Reed Richards / Mr. Fantastic

Jessica Alba as Sue Richards / Invisible Woman

Chris Evans as Johnny Storm / Human Torch

Michael Chiklis as Ben Grimm / The Thing

Julian McMahon as Victor von Doom / Doctor Doom

Doug Jones as Norrin Radd / Silver Surfer

Kerry Washington as Alicia Masters

Andre Braugher as General Hager

Laurence Fishburne as Norrin Radd / Silver Surfer (voice)

Beau Garrett as Frankie Raye

Brian Posehn as Priest

Zach Grenier as James Sherman / Rafke

Kenneth Welsh as Dr. Jeff Wagner

Kevin McNulty as Baxter Building Doorman

Andy Stahl as Tailor

Debbie Timuss as Hot Party Girl #1

Moneca Delain as Hot Party Girl #2

Yan-Kay Crystal Lowe as Hot Party Girl #3

Vanessa Lachey as Johnny's Wedding Date

Stan Lee as Stan Lee - Rejected Wedding Guest

Gonzalo Menendez as Lieutenant

Giuliana Rancic as Entertainment Reporter

Lauren Sánchez as Fox News Reporter

Benjamin Ayres as Guard #1

Patricia Harras as Fan Four Receptionist

Fareed Abdelhak as Egyptian Tour Guide

Dawn Chubai as Anchorwoman

Alicia Thorgrimsson as New York Pedestrian

Valerie Tian as New York Teen Girl #1

Jeanna Haddow as New York Teen Girl #2

Ali Costigan as New York Teen Girl #3

Suzanne Ristic as Airline Woman

Michasha Armstrong as Wedding Security

Ulla Friis as Danish News Anchor (uncredited)

Nimet Kanji as Tourist in Egypt (uncredited)