Ioan Gruffudd as Reed Richards / Mr. Fantastic

Jessica Alba as Sue Storm / Invisible Woman

Chris Evans as Johnny Storm / Human Torch

Michael Chiklis as Ben Grimm / The Thing

Julian McMahon as Victor von Doom / Doctor Doom

Hamish Linklater as Leonard

Kerry Washington as Alicia Masters

Laurie Holden as Debbie McIlvane

David Parker as Ernie

Kevin McNulty as Jimmy O'Hoolihan

Maria Menounos as Sexy Nurse

Michael Kopsa as Ned Cecil

Andrew Airlie as Compound Doctor

Pascale Hutton as Nightclub Girlfriend

G. Michael Gray as Nightclub Boyfriend

David Richmond-Peck as Gallery Patron

Penelope Parkes as Bohemian Girl 1

Aonika Laurent as Bohemian Girl 2

Jason Schombing as Bridge Businessman

Jason Diablo as NYPD Bridge Cop 1

Colin Lawrence as NYPD Bridge Cop 2

Paul Belsito as NYPD Bridge Cop 3

Dee Jay Jackson as Chief Fireman

Morgan Reynolds as Corvette Redhead

Gina Holden as LV Receptionist

Donavon Stinson as X Games Announcer

Douglas Weston as Victor's Doctor

Tony Alcantar as Compound Reporter #1

Brenda Crichlow as Compound Reporter #2

Peter Bryant as Lame Joke Businessman

Lorena Gale as Old Lady With Car #1

Danielle Dunn-Morris as Old Lady With Car #2

Nicole Muñoz as Little Girl

Daniel Bacon as Bridge Reporter

Bobby Bysouth as Compound Reporter #3

Kenny Bartram as Himself

Ronnie Renner as Himself

Brian Deegan as X Games Rider

Marlaina Mah as Lusting Model

Tre Verhoeven as Lusting Model

Juanita Mirehouse as Lusting Model

Stefanie Singer as Lusting Model

Jamie Little as X Games Reporter

Doug Abrahams as Truck Driver

Ron Chartier as Hotel Guest

Stan Lee as Willie Lumpkin

Barbara Christabella as Girl in Park

Sanja Banic as Girl in Park

Ed Hodson as Construction Worker

John Speredakos as Construction Worker

Jason Kaufman as Cop

Preston Thomas Peet as Goth Guy

Steven Fulani Hart as Newsstand Pedestrian

Bethann Schebece as Newsstand Pedestrian

Lou Torres as Cab Driver

Peggy Gormley as Homeless Woman

Maurice Tyson as Homeless Guy

Jaimie McVittie as Little Girl On Bridge

Jenni Squair as Elevator Lady

Lia Salmond as Elevator Lady

Ellen Ewusie as Elevator Lady

Ylenia Aurucci as Elevator Lady

Michelle Zembruski as Elevator Lady

Kathleen Mullan as Elevator Lady

Georgia Dewson as Elevator Lady

Sienna Rose as Storm's Fan

Hector A. Leguillow as Newsstand Vendor

Ben Mulroney as Etalk Daily CTV

Terry David Mulligan as CityTV

Lauren Sánchez as KCOP / KTTV

Mark S. Allen as KMAX-TV(IND) Sacramento

Jon Brady as Fox Network News

Taryn Winter Brill as Aol.com

Sara Edwards as The Comcast Network

Heidi Eng as King-TV(NBC) Seattle

Jim Ferguson as ABC-KGUN 9-TV Tucson

Sam Hallenbeck as NBC Tampa

Mike Waco as Fox Network News

Marian Etoile Watson as UPN 9 / Fox

Richard Ho as Wizard: The Comics Magazine

Dave Holmes as FX

Andrew Hunsaker as Yahoo Entertainment

Taylor Johnson as MSN.com

Bonnie Laufer-Krebs as Tribute TV

Lisa Fuller Magee as KTVK-TV(IND) Phoenix

Bret Martin as Fox 5 / WAGA Atlanta

Liam Mayclem as KRON-TV(IND) San Francisco

Scott Patrick as KUSA-TV(NBC) Denver

Shaheem Reid as MTV News

Sam Rubin as KTLA

Maria Salas as NBC Entertainment Reporter Miami

Devon Soltendieck as MuchMusic

Patrick Stoner as WHYY-TV Philadelphia

Lee Thomas as Fox 2 Detroit

Tony Toscano as Talking Pictures / KJZZ-TV(IND) Salt Lake City

Jennifer Lothrop as FX

Doug Chapman as Fireman Hanging Off Bridge (uncredited)

Sean Bennett as Newsstand Pedestrian (uncredited)

Christopher Gordon as Fireman (uncredited)

Richard Rigby as Cafe Patron / Party Goer (uncredited)

Yvonne Myers as Principal (uncredited)

Ralph Winter as Ship Worker (uncredited)

Lynnanne Zager as Computer (voice) (uncredited)