Jesse Eisenberg as Columbus

Woody Harrelson as Tallahassee

Emma Stone as Wichita

Abigail Breslin as Little Rock

Amber Heard as 406

Bill Murray as Bill Murray

Derek Graf as Clown Zombie

Elle Alexander as Zombie Meter Maid (uncredited)

Melanie Booth as Hippie Girl (uncredited)

Chris Burns as Bicycle Zombie (uncredited)

Blaise Corrigan as Groom (uncredited)

Sydnie Dawson as Princess Zombie (uncredited)

Justin Price as Sprint Zombie (uncredited)

Christina Klein as Zombie (uncredited)

Amir Kovacs as Zombie (uncredited)

Shaun Lynch as Cardio Zombie (uncredited)

Lynn McArthur as Girl on Cell Phone (uncredited)

Michelle Sebek as Businesswoman Zombie (uncredited)

Victory Van Tuyl as Bubby & Pee Paw's Granddaughter (uncredited)

Mike White as Toilet Victim / Gas Station Attendant (uncredited)

Cesar Aguirre as Customer at the Pump (uncredited)

Daniel Burnley as Frightened Pedestrian (uncredited)

Ernest Dancy as Businessman Zombie (uncredited)

Jon Gould as Pedestrian in Decatur (uncredited)

Travis Grant as Amusement Park Zombie (uncredited)

Robert Hatch as Yuppie Zombie (uncredited)

Jeh Howell as Zombie (uncredited)

Amir R. Khan as Point-Blank Zombie (uncredited)

Suzanne LaChasse as Zombie (uncredited)

Kurt McNew as Amusement Park Zombie (uncredited)

Stephen Prouty as Punched in Face Zombie (uncredited)

Ming Qiu as Achilles Businesswoman (uncredited)

Rhett Reese as Tuxedo Guy with AK-47 (uncredited)

April Rich as Hot Mom (uncredited)

Cody Rowlett as Panicked Pedestrian (uncredited)

Joan Schuermeyer as Cynthia Knickerbocker (uncredited)

Brian Stretch as DC Zombie (uncredited)

Sonya Thompson as Lunchroom Lady Zombie (uncredited)

Clay Walker as Mechanic (uncredited)

Steve Warren as Metro Station Zombie (uncredited)

Travis Young as Grocery Store Zombie (uncredited)