Akshay Kumar as Rajiv

Katrina Kaif as Sanjana Shetty

Nana Patekar as Uday Shetty

Anil Kapoor as Majnu Bhai

Paresh Rawal as Dr. Ghungroo

Supriya Karnik as Payal Ghungroo

Feroz Khan as Ranvir Dhanraj Xaja "RDX"

Mallika Sherawat as Isha-Ishika

Sherveer Vakil as Lucky Xaxa

Vijay Raaz as Dhanesh Varman

Asrani as Film Producer (uncredited)

Sanjay Mishra as Pandit

Snehal Dabi as Kakhil

Adi Irani as Harkesh Sahni

Mushtaq Khan as Ballu

Paresh Ganatra as Pappu

Malaika Arora as Item Number In Song Hoth Rasiley

Om Puri as Narrator (uncredited)

Ruslaan Mumtaz as Himself (uncredited)

Suniel Shetty as Himself (uncredited)