Frank Welker as Scooby-Doo / Fred (voice)

Mindy Cohn as Velma (voice)

Grey DeLisle as Daphne (voice)

Matthew Lillard as Shaggy (voice)

Isabella Acres as Emma Gale (voice)

Troy Baker as The Phantom / Lance Damon (voice)

Eric Bauza as K.J. (voice)

Jeff Bennett as Mike Gale/ Mel Richmond (voice)

Wayne Brady as Brick Pimiento (voice)

Vivica A. Fox as Lotte Lavoie (voice)

Kate Higgins as Meg Gale / Cathy (voice)

Peter MacNicol as Dewey Ottman (voices)

Candi Milo as Barb Damon (voice)

John O'Hurley as The Great Pauldini (voice)

Cristina Pucelli as Colette (voice)

Kevin Michael Richardson as Security Guard #1 / Hotel Clerk (voice)

Paul Rugg as Steve Trilby (voice)

Tara Sands as Nancy (voice)

Tara Strong as News Anchor / Donna (voice)

Travis Willingham as Waldo (voice)

Ariel Winter as Chrissy Damon (voice)