Frank Welker as Scooby-Doo / Fred Jones / Dynomutt (voice)

Mindy Cohn as Velma Dinkley (voice)

Grey DeLisle as Daphne Blake (voice)

Matthew Lillard as Shaggy Rogers (voice)

Diedrich Bader as Brad Adams (voice)

Dee Bradley Baker as Hideous Hyde Hound / Horten / Minotaur (voice)

Jeff Bennett as Owen Garrison (voice)

Gregg Berger as Hank Prince / Zorak (voice)

John DiMaggio as Mr. Hyde (voice)

Nika Futterman as Jennifer Severin (voice)

Kevin Michael Richardson as Mayor Ron Starlin (voice)

Mindy Sterling as Caterer (voice)

Tara Strong as Austin / Princess Garogflotach (voice)

Fred Tatasciore as Jack Rabble / Cruel Dynomutt (voice)

Billy West as Becker (voice)