Ricky Gervais as Mark Bellison

Jennifer Garner as Anna McDoogles

Louis C.K. as Greg Kleinschmidt

Rob Lowe as Brad Kessler

Jonah Hill as Frank Fawcett

Jeffrey Tambor as Anthony James

Fionnula Flanagan as Martha Bellison

Tina Fey as Shelley Bailey

Donna Sorbello as Anna's Mother

Jason Bateman as Doctor

Philip Seymour Hoffman as Jim the Bartender

Jimmi Simpson as Bob

Stephanie March as Blonde

Ruben Santiago-Hudson as Landlord

John Hodgman as Wedding Overseer

Nate Corddry as News Reporter

Christopher Guest as Nathan Goldfrappe

Alton Fitzgerald White as Angelo Badsmith

Edward Norton as Cop

Shaun Williamson as Richard Bellison

Stephen Merchant as Man at the Door

Michael Patrick Gough as Homeless Man

Ashlie Atkinson as Bank Teller

Lisa Paige Robinson as Arguing Girlfriend

Matt Stadelmann as Arguing Boyfriend

Martin Starr as Waiter #1

Tate Ellington as Waiter #2

Arnie Burton as Waiter at Fancy Restaurant

Bobby Moynihan as Assistant

Cole Jensen as Short Fat Brian

Conner Rayburn as Son

Roz Ryan as Nurse #1

Nada Despotovich as Nurse #2

Jared Voss as Person #1

Jessica Baade as Person #2

Elena Wohl as Person #3

Matthew Robinson as Person #4

Donald Foley as Yelling Man

Patrick Shea as Man #7

Joe Stapleton as Man #8

Dennis Lemoine as Young Man

Lance Norris as Man #1

Joe Wong as Man #2

Collin Knight as Man #3

Eric André as Man #4

Gene Amoroso as Man #5

Armen Garo as Man #6

Dreama Walker as Receptionist

Brigid O'Connor as Woman #1

Christine Mascott as Woman #2

Ellen Colton as Woman #3

Layla Hosseini as Woman #4

Erica Newhall as Woman #5

Nydia Calon as Woman #6

Hope Farley as Woman #7

Paul Donlon as Elderly #1

Mauriel Gould as Elderly #2

Mary Klug as Elderly #3

Rachel Harker as Woman in Business Suit

Brett Cramp as Crying Man

Toni Saladna as Cocktail Waitress

Guy Strauss as Pit Man

Nick Towne as Roulette Dealer

Luz Alexandra Ramos as Chip Woman

Ken Cheeseman as Shouting Man

David Pittu as Tour Guide

Danielle Perry as Hostess in La Bonisera

Joseph Badalucco Jr. as Blue Collar Guy

Douglass Bowen Flynn as Tourist #1

Celeste Oliva as Secretary

Jake Watkins as Bully Kid

Valerie Hager as Talking Head Woman

Alison Quinn as Talking Head Woman

Mitchell Roche as Talking Head Man

John Franchi as Casino Gambler (uncredited)