Gérard Depardieu as Obélix

Clovis Cornillac as Astérix

José Garcia as Couverdepus

Franck Dubosc as Assurancetourix

Stéphane Rousseau as Alafolix

Jean-Pierre Cassel as Panoramix

Mónica Cruz as Esmeralda

Alain Delon as Jules César

Benoît Poelvoorde as Brutus

Vanessa Hessler as Princess Irina

Michael Herbig as Pasunmotdeplus

Santiago Segura as Doktormabus

Bouli Lanners as King Aderlas

Adriana Karembeu as Madame Methusalix

Jérôme Le Banner as Claudius Muscullus

Alexandre Astier as Obstinatus

Luca Bizzarri as Alpha

Paolo Kessisoglu as Beta

Élie Semoun as Omega

Francis Lalanne as Lalanix

Michael Schumacher as Schumix

Zinédine Zidane as Numérodis

Tony Parker as Tonus Parker

Sim as Agecanonix

Patrice Thibaud as Coach

Stéphane De Groodt as Numerix

Nathan Jones as Humungus

Dany Brillant as Le goûteur de miroir

Vincent Moscato as Le lutteur de la délégation de Rhodes

Dorothée Jemma as Bonemine

Tony Gaultier as Ordralfabétix

Pierre Tchernia as Le narrateur (voice)

Enrico Brignano as Commentatore sportivo

Jean Todt as il padrone di Schumix

Jamel Debbouze as Numérobis (uncredited)

David M. Antón as Romano