Christian Clavier as Astérix

Gérard Depardieu as Obélix

Jamel Debbouze as Numérobis

Claude Rich as Panoramix

Alain Chabat as Jules César

Gérard Darmon as Amonbofils

Édouard Baer as Otis

Monica Bellucci as Cléopâtre

Isabelle Nanty as Itinéris

Dieudonné as Caius Céplus

Mouss Diouf as Baba, pirate lookout

Marina Foïs as Sucettalanis

Bernard Farcy as Captain Barbe-Rouge

Jean Benguigui as Malococsis

Michel Crémadès as Triple-Patte

Jean-Paul Rouve as Caius antivirus

Édouard Montoute as Nexusis

Chantal Lauby as Cartapus

Noémie Lenoir as Guimieukis

Fatou N'Diaye as Exlibris

Dominique Besnehard as Taster

Zinedine Soualem as Tiler

Mohamed Nesrate as Head of the guards

Joël Cantona as Centurion of the gaul forest

Cyril Raffaelli as Legionary of the gaul forest

Sophie Noël as Daughter of Barbe-Rouge

Philippe Chany as Maori Nataf

Robert Kechichian as Member of the pirate crew

Christian Gazio as Member of the pirate crew

Louis Leterrier as Ouhécharlis

Yves Domenjoud as ZZ Top worker

Bruno Vatin as ZZ Top worker

Emma de Caunes as César's secretary

Momo Debbouze as Sphinx seller

Abdel Soufi as Sculptor

Océane Lavergne as Amazon of César

Claude Berri as Portrait painter of Cléopâtre

Atik Mohamed as Gardener

Patrick Bordier as Menubestofplus

Pierre Tchernia as Caius Gaspachoandalus / Le narrateur

Alessandro Freyberger as Caius Tchounus Mogulus

Victor Loukianenko as Brutus

Candide Sanchez as Repulsed legionnaire

Cyril Casmèze as Four legged legionnaire

Pascal Vincent as Catapult legionnaire

Pierre-François Martin-Laval as Catapult launcher

Jean-Pierre Lazzerini as Laconic legionary 1

Xavier Maly as Laconic legionary 2

Maurice Barthélemy as Couloirdebus, legionnaire

Laurent Biras as Francorus, legionary

Emmanuel Lanzi as Roman catapulted

Mathieu Kassovitz as Banquet physiognomist

Jean-Pierre Bacri as Lobster commentator (voice)

Thierry Desroses as Voix Numérobis ("Et c'est qui le lion maintenant ?")