Édouard Baer as Astérix

Gérard Depardieu as Obélix

Guillaume Gallienne as Jolitorax

Vincent Lacoste as Goudurix

Valérie Lemercier as Miss Macintosh

Fabrice Luchini as Jules César

Catherine Deneuve as Cordelia la reine d'Angleterre

Charlotte Le Bon as Ophélia

Bouli Lanners as Grossebaf

Dany Boon as Têtedepiaf

Atmen Kelif as Pindépis

Jean Rochefort as Lucius Fouinus

Gérard Jugnot as Le capitaine Barbe-Rouge

Luca Zingaretti as Général

Filippo Timi as Décurion patrouille

Niccolò Senni as Megacursus

Neri Marcorè as Décurion patrouille

Tristán Ulloa as Claudius Lapsus

Javivi as Le bourreau

Götz Otto as Yadutaf

Stéphane De Groodt as Le décurion du stade

Gaëlle Jeantet as Bonemine

Christophe Denis as Baba, la vigie des pirates

Jacques Herlin as Triple-Patte

Laura Boujenah as La jeune gauloise