Uma Thurman as The Bride

Lucy Liu as O-Ren Ishii

Vivica A. Fox as Vernita Green

Daryl Hannah as Elle Driver

David Carradine as Bill

Michael Madsen as Budd

Julie Dreyfus as Sofie Fatale

Chiaki Kuriyama as Gogo Yubari

Sonny Chiba as Hattori Hanzo

Gordon Liu Chia-Hui as Johnny Mo

Michael Parks as Earl McGraw

Michael Bowen as Buck

Jun Kunimura as Boss Tanaka

Kenji Ohba as Bald Guy (Sushi Shop)

Yuki Kazamatsuri as Proprietor

James Parks as Edgar McGraw

Sakichi Sato as Charlie Brown

Jonathan Loughran as Trucker

Yoshiyuki Morishita as Tokyo Business Man

Tetsuro Shimaguchi as Crazy 88 #1 (Miki)

Kazuki Kitamura as Crazy 88 #2

Yoji Tanaka as Crazy 88 #3

Issey Takahashi as Crazy 88 #4

Sō Yamanaka as Crazy 88 #5

Juri Manase as Crazy 88 #6 (Girl)

Akaji Maro as Boss Ozawah

Goro Daimon as Boss Honda

Shun Sugata as Boss Benta

Zhang Jinzhan as Boss Orgami

Hu Xiaohui as Young 88 (Spanked Boy)

Ambrosia Kelley as Nikki Bell

Sachiko Fujii as The 5, 6, 7, 8's

Yoshiko Yamaguchi as The 5, 6, 7, 8's

Ronnie Yoshiko Fujiyama as The 5, 6, 7, 8's

Shu Lan Tuan as Okinawa Airline Ticket Agent

Ai Maeda as O-Ren (anime sequence) (voice)

Naomi Kusumi as Boss Matsumoto (anime sequence) (voice)

Hikaru Midorikawa as Pretty Riki (anime sequence) (voice)