Stewart Granger as Sherlock Holmes

Bernard Fox as Dr. Watson

William Shatner as George Stapleton

Anthony Zerbe as Dr. John Mortimer

Sally Ann Howes as Laura Frankland

Jane Merrow as Beryl Stapleton

Ian Ireland as Sir Henry Baskerville

John Williams as Arthur Frankland

Alan Caillou as Insp. Lestrade

Brendan Dillon as Barrymore

Arline Anderson as Eliza Barrymore

Liam Dunn as Messenger

Michael St. Clair as Constable

Barry Bernard as Manager

Constance Cavendish as Eel Monger

Billy Bowles as Billy Cartwright

Arthur Malet as Higgins

Karen Kondazian as Mrs. Mortimer

Elaine Church as Maid Servant

Jenifer Shaw as Peasant Girl

Terence Pushman as Chestnut Vendor

Eric Brotherson as Porter