Frank Welker as Fred Jones / Scooby-Doo (voice)

Matthew Lillard as Shaggy Rogers (voice)

Grey DeLisle as Daphne Blake (voice)

Mindy Cohn as Velma Dinkley (voice)

April Jeanette Mendez as AJ Lee (voice)

Mary McCormack as Ms. Richards (voice)

John Cena as Himself (voice)

Michael Coulthard as Michael Cole (voice)

Glenn Jacobs as Kane (voice)

George Murdoch as Brodus Clay (voice)

Anthony Carelli as Santino Marella (voice)

Mike Mizanin as The Miz (voice)

Paul Lévesque as Triple H (voice)

Vince McMahon as Himself (voice)

Corey Burton as Bayard / Announcer (voice)

Bumper Robinson as Ruben (voice)

Fred Tatasciore as The Bear (voice)

Charles S. Dutton as Cookie (voice)