John Candy as Frank Dooley

Eugene Levy as Norman Kane

Robert Loggia as Michael Carlino

Kenneth McMillan as Captain Clarence O'Connell

Meg Ryan as Maggie Cavanaugh

Brion James as Anthony Lazarus

Jonathan Banks as Clyde Klepper

Don Stroud as Sergeant Rizzo

Larry Hankin as Kokolovitch

Steve Railsback as The Cowboy

Robert Burgos as Mel Nedler

Tony Burton as Cappy

Robert Gray as Butcher

Larry Jenkins as Raisin

Stacy Keach, Sr. as Judge

Bruce Kirby as Police Captain

Savely Kramarov as Olaf

Judy Landers as Noreen

Tommy Lister Jr. as Bruno

James Tolkan as Lou Brackman

K.C. Winkler as Vicki

Glenn Withrow as Larry Lupik

David Wohl as Prosecutor

Melanie Gaffin as Little Girl

Ira Miller as 1st Toxic Guard

Royce D. Applegate as 2nd Toxic Guard

John Solari as Dolan

David Hess as Gunman #4

Christine Dupree as Peep Show Girl

Nicholas Worth as Transvestite

Sylvia Kauders as Older Woman at Party

Wilson Camp as Older Man at Party

Edith Fields as Party Guest

J. Jay Saunders as Mayor

Tito Puente as Band Leader

Rick Avery as Cobb

Joe Seely as Kid

Mark Carlton as Court Clerk

Teagan Clive as Staff Member