John Candy as Jack Gable

Mariel Hemingway as Janet Dubois / Louise

Emma Samms as Rachel Hedison / Laura Claybourne

Raymond Burr as Carter Hedison

Dylan Baker as Blake Hedison

Charles Rocket as Ty Hedison

David Rasche as Dr. Paul Kirkwood / Dennis

Andrea Thompson as Nurse Helen Caldwell

Zach Grenier as Mickey

Jerry Orbach as Lou Sherwood

Renée Taylor as Arlene Sherwood

Milt Oberman as Fetterman

Mark Boone Junior as Cable Man

Tony Steedman as Edward

John Michael Bolger as Len

Rita Gomez as Marge

Stephanie Segal as TV Reporter

Mark Zuelke as Chauffeur

Dick Durock as Riley

Anthony G. Schmidt as Mason

Murray Rubin as Manny

Peter Bromilow as Auctioneer

Patrick Bristow as Bellboy

Jason Ross-Azikiwe as Manu

Brooke Ashley as Cheerleader Donna McKenzie

Glenn Dixon as Elderly Man

Paul Tuerpe as Waiter

Fred Morsell as Choking Man

Zack Phifer as Attendant

Susan Isaacs as Marie

Marvin Kaplan as Typewriter Repairman

Elaine Swayneson as Secretary

Jay Della as Ashford Falls Cable Man

Michael Caldwell as Busboy

Bill Wittman as Soap Announcer

Robert M. Bouffard as Office Clerk (uncredited)

Robert David Crane as Bob (uncredited)

Margot Kidder as Woman in Washroom (uncredited)

Tom Mankiewicz as Man on Stretcher (uncredited)

Robert Wagner as Jack Gates (uncredited)