Amy Schumer as Amy Townsend

Bill Hader as Dr. Aaron Conners

Brie Larson as Kim

LeBron James as LeBron James

Colin Quinn as Gordon Townsend

Mike Birbiglia as Tom

Evan Brinkman as Allister

John Cena as Steven

Tilda Swinton as Dianna

Vanessa Bayer as Nikki

Ezra Miller as Donald

Randall Park as Bryson

Jon Glaser as Schultz

Amar'e Stoudemire as Amar'e Stoudemire

Dave Attell as Noam

Norman Lloyd as Norman

Method Man as Temembe

Claudia O'Doherty as Wendy

Bridget Everett as Kat

Nikki Glaser as Lisa

Tim Meadows as Tim

Kyle Dunnigan as Kyle

Kevin Kane as Kevin

Keith D. Robinson as Guy in Back of Theater

Marina Franklin as Woman in Back of Theater

Matthew Broderick as Matthew Broderick

Marv Albert as Marv Albert

Chris Evert as Chris Evert

Daniel Radcliffe as The Dogwalker

Marisa Tomei as The Dog Owner

Tony Romo as Tony Romo

Devin Fabry as Nine-Year-Old Amy

Carla Oudin as Five-Year-Old Kim

Josh Segarra as Staten Island Oli

Ryan Farrell as One-Night-Stand Guy

Robert E. Torres as One-Night-Stand Guy

Jim Florentine as One-Night-Stand Guy

Robert Kelly as One-Night-Stand Guy

Pete Davidson as Dr. Conners' Patient

Dan Soder as Dumpster Guy

Leslie Jones as Angry Subway Patron

Estee Adoram as Jostled Subway Patron

Dave Hanson as Alice's Tea Cup Waiter

Kim Caramele as S'nuff Receptionist

Max Alexander as Max the Wheelchair Orderly

Criscia Richardson as Injured Knicks City Dancer

Alva Chinn as Benefit Guest

Arnold Y. Kim as Benefit Guest

Rob Buntzen as Benefit Guest

Karen Chamberlain as Awards Luncheon Coordinator

Ajay Mehta as Dr. Raj

Rachel Feinstein as Nurse Rachel

Victoria Dicce as Donald's Mother

Lisa K. Price as Woman on Bench with One-Hitter

Kevin Thompson as Vanity Fair Editor

Leah O'Donnell as Dancer

Selena Watkins as Dancer

Alicia Mazepa as Dancer

Nicole Serapiglia as Dancer

Amanda Robinson as Dancer

Whitney Wiggins as Dancer

Alexa Kobylarz as Dancer

Ashley Nuel as Dancer

Michelle Roe as Dancer

Teal DePaola as Dancer

LaToya Brooks as Dancer

Kerrie Greene as Dancer

Jess Attardo as Dancer

Alyssa Quezada as Dancer

Javoris Carlisle as Trampoline Dunker

Aidan Charlery as Trampoline Dunker

Warren E. Hull as Trampoline Dunker

Eric Locklin as Trampoline Dunker

Luciano Acuna Jr. as Trampoline Dunker

Derric J. Stotts as Trampoline Dunker

Sterling Jones as Trampoline Dunker

Emma Jonnz as Annalisa (uncredited)

Tommy Bayiokos as Gordon's Friend (uncredited)

Roger Brenner as Fredderick the Anesthesiologist (uncredited)

Tim Duquette as Gordon's Sad 'Ol Paleo at Funeral (uncredited)

Henry Gagliardi as Amy's Son (uncredited)

Eddie K. Robinson as S'nuff Magazine Employee (uncredited)

Booker Garrett as Walk of Shame (uncredited)

Robert Z. Grant as Walk of Shame (uncredited)

Matthew Herington as Walk of Shame (uncredited)

Rock Kohli as Walk of Shame (uncredited)

Diane Kimbrell as Assisted Living Resident (uncredited)

Doris McCarthy as Assisted Living Resident (uncredited)

Parker Madison as Doctor (uncredited)

John Mainieri as Mob Bar Bartender (uncredited)

Tony Cheng as Bartender (uncredited)

Patrick J. Curley as Bartender (uncredited)

Krista Tunnell as Waitress (uncredited)

Joe Mancini as Wiseguy (uncredited)

Khalil Muhammad as Security Guard (uncredited)

Jessica Cherniak as Benefit Guest (uncredited)

Christine Duke as Courtside Fan