Eric Gilliland as Spud (voice)

Sarah Silverman as Cherri (voice)

Dermot Mulroney as Rod (voice)

Beverly D'Angelo as Darlene (voice)

David Carradine as Mr. Snerz (voice)

Keith Carradine as JoJo (voice)

Martha Plimpton as Miss Crumbles (voice)

Tom Noonan as Principal (voice)

Zak Orth as Zip (voice)

Justin Long as Dwayne (voice)

Michael Showalter as Wally (voice)

Hayley DuMond as Buttercup (voice)

Ed Begley Jr. as Rev. Sidney Cheddar (voice)

Craig Bierko as Sarge (voice)

Jay O. Sanders as Football Announcer (voice)

Peter Jason as Coach (voice)

Matt Groening as Will (voice)

Don Hertzfeldt as Dill (voice)