Edward Norton as Will Graham

Anthony Hopkins as Hannibal Lecter

Ralph Fiennes as Francis Dolarhyde

Emily Watson as Reba McClane

Harvey Keitel as Jack Crawford

Philip Seymour Hoffman as Freddy Lounds

Anthony Heald as Dr. Chilton

Mary-Louise Parker as Molly Graham

Tyler Patrick Jones as Josh Graham

Ken Leung as Lloyd Bowman

Frankie Faison as Barney

Lalo Schifrin as Conductor

Tim Wheater as Flautist

John Rubinstein as Dinner Guest

David Doty as Dinner Guest

Brenda Strong as Dinner Guest

Robert Curtis Brown as Dinner Guest

Mary Anne McGarry as Dinner Guest

Marc Abraham as Dinner Guest

Veronica De Laurentiis as Dinner Guest

Michael Cavanaugh as Forensic Dentist

Madison Mason as Police Commissioner

Bill Duke as Police Chief

Cliff Dorfman as Cop

Phillip B. Fahey as Cop

Tom Verica as Charles Leeds

Marguerite MacIntyre as Valerie Leeds

Thomas Curtis as Billy Leeds

Azura Skye as Bookseller

Jeanine Jackson as Dr. Hassler

William Lucking as Byron Metcalf

Katie Rich as Woman Detective

Alex Berliner as Photographer

Ellen Burstyn as Grandma Dolarhyde (voice) (uncredited)

Mary Beth Hurt as Museum Curator (uncredited)

James Pickens Jr. as Male Zoo Doctor (uncredited)

Frank Whaley as Ralph Mandy (uncredited)

Tanya Newbould as Chromalux Secretary

Elizabeth Dennehy as Beverly

Joseph Simmons as Janitor

Mark Moses as Father in Video

Norman Fessler as Driver (uncredited)

Alex D. Linz as Young Dolarhyde (voice)

Jordan Gruber as Sean Leeds

Morgan Gruber as Susie Leeds

Richard Pelzman as Locksmith

Andreana Weiner as Dr. Bloom's Secretary

Stanley Anderson as Jimmy

Terence Rowley as Superintendent

Gianni Russo as Newsie

Al Brown as Tattler Guard

Edward Nickerson as FBI Agent

Kyra Helfrich as Child in Video

Frank Bruynbroek as Chef

Dwier Brown as Mr. Jacobi

Grace Stephens as Jacobi Child

Lucy Stephens as Jacobi Child

Kevin Bashor as Jacobi Child

Hillary Straney as Museum Secretary

Christopher Curry as Mr. Fisk

Conrad E. Palmisano as Deputy in Car

Tony Reynolds as FBI Agent