Adrien Brody as Psycho Ed

Matt Bush as Henry Burke

Sean Marquette as Travis Breaux

Colin Hanks as Brandon Ellis

Michael Chiklis as Dr. Leslie Gordon

Adhir Kalyan as Sebastian Saleem

Mykelti Williamson as Paranoid

Luis Chávez as Big Dave

Max Van Ville as Little Dave

Brett Kelly as Martin Gordon

George Back as Malcolm

Alicia Sixtos as Sharky Ovante

Andrew Wilson as Hippie Dude

Camille Mana as Dana

Erica Vittina Phillips as Tameka

Arcadiy Golubovich as Edwin Hunter

Julia Ling as Charlyne

Cody Longo as Chad

Mary Birdsong as Mrs. Gordon

Yeardley Smith as Computer Skills Teacher

Curtis Armstrong as Mr. Thompson

Alex Biats as Spelling Bee Rival

John Beard as Male News Desk Reporter

Barret Swatek as Female News Desk Reporter

Rhys Coiro as Vato

Wyatt Russell as Drug PSA Stoned Teenager

Mike Eshaq as Lead Terrorist

Heather Elizabeth Regan as Cheerleader who collides with Henry

Terri Lyn Rodriguez as Vivian

Robert Bailey Jr. as Jeffrey

Kelli Rasmus as Hippie Chick

Shirley Benyas as Older Female Donor

Wallace Bridges as African American Donor

Carl Harry Carlson as Donor #1

Randy Godwin as Donor #2

Mike Evans as Donor #3

Linda Boston as Head Nurse

Nadine Crocker as Emily Tooms

Clarence Smith as Chess Opponent

Ron Ayers as Stunned Lawn Bowler

Karl Murphy as Band Teacher

Rachel Quaintance as Angry Parent #1

Peter Tocco as Angry Parent #2

Mike Woods as Announcer

Kerry Birmingham as Female Reporter

Kevin Yon as Mr. Cavanaugh

Sammy A. Publes as Cook #1

Rene Santana as Cook #2

Billye Thompson as Cop #1

J. J. Soria as Rubin

David Herbst as School Security Guard

John O'Hurley as Drug PSA (voice)

John Stalberg Jr. as Grandpa Frodo - Ed's Frog (voice)

Heather Kleisner as Henry's Mom (voice)

D.B. Dickerson as Stoned High School Student (uncredited)

Sabrina Dungan as High School Student (uncredited)

Penny Gibbs as School Admin (uncredited)

Adam Lorenz as Dwayne Reynolds (uncredited)

Bill Lumbert as Concerned Parent (uncredited)

Misty Mills as Teacher (uncredited)

Jerry Reid as High School Student (uncredited)

Steven Sutherland as Academy Student (uncredited)

Joe Tinpan as Terrorist (uncredited)

Michael Vartan as Calculus Teacher (uncredited)

Amanda Bright as High School Student (uncredited)

Kathi J. Moore as Librarian