Fred MacMurray as Neal Harris

William Bishop as Captain George Wayne

Nina Shipman as Prudence Cooper

Gloria Talbott as Shona Hastings

Henry Hull as George Seton

John Carradine as Zachariah Garrison

John Dierkes as Gabe Hastings

Roxene Wells as Flossie Shoemaker

Elizabeth Patterson as Maria Cooper

Gene N. Fowler as Richard Cooper

James Bell as Jeremiah Cooper

John Slosser as Johnny

Ralph Sanford as John Decker

Sherry Spalding as Lucy

Tex Terry as Brizzard

Ollie O'Toole as James Gordon Bennett

Arvo Ojala as Ellis

Ed Wright as Jesse

Addison Richards as President James Polk (uncredited)

Lumsden Hare as Sir Richard Wallingham (uncredited)

Oscar Beregi Jr. as Ralph Clayman (uncredited)

Chet Brandenburg as Wagon Train Member at Fort (uncredited)

Raven Grey Eagle as Indian (uncredited)

Jim Whitecloud as Indian (uncredited)

Harry 'Snub' Pollard as Townsman (uncredited)

Al Haskell as Townsman (uncredited)

James Dime as Townsman (uncredited)

Sally Yarnell as Townswoman (uncredited)