Paul Newman as John Russell

Fredric March as Dr. Alex Favor

Richard Boone as Cicero Grimes

Diane Cilento as Jessie

Cameron Mitchell as Frank Braden

Barbara Rush as Audra Favor

Peter Lazer as Billy Lee Blake

Margaret Blye as Doris Blake

Martin Balsam as Henry Mendez

Skip Ward as Steve Early

Frank Silvera as Mexican Bandit

David Canary as Lamar Dean

Val Avery as Delgado

Larry Ward as Soldier

Linda Cordova as Mrs. Delgado (uncredited)

Pete Hernandez as Apache (uncredited)

Merrill C. Isbell as Apache (uncredited)