Ron Fazio as The Toxic Avenger / Apocalypse, Inc. Executive

John Altamura as The Toxic Avenger

Rick Collins as Apocalypse, Inc. Chairman / The Devil

Phoebe Legere as Claire

Lisa Gaye as Malfaire

Tsutomu Sekine as Announcer

Jessica Dublin as Mrs. Junko

Michael J. Kaplan as Little Melvin

Traci Mann as Snake Lady / Apprentice Bad Girl

Paul Borghese as Lou Sipher

Joe Fleishaker as Apocalypse, Inc. Executive

Michael Jai White as Apocalypse, Inc. Executive

Pericles Lewnes as Painted Face Villain

Ara Romanoff as Video Store Employee

Carl Burrows as Doctor Goldberg (as Edward Burrows)

William E. Benson as Father O'Reilly

Dan Snow as Cigar Face

Bonnie Garvin as Bad Girl

Karen King as Bad Girl

Dee Dee Mancuso as Bad Girl

Melissa Osborne as Bad Girl

Helen Wheels as Bad Girl

Raven Skye as Apprentice Bad Girl

Fernando Antonio as Apocalypse, Inc. Executive

Sylvester Covin as Apocalypse, Inc. Executive

Paul Davis as Apocalypse Inc. Employee

William Decker as Apocalypse Inc. Executive

Mark Fucile as Apocalypse, Inc. Executive