Clark Gable as Edward J. 'Blackie' Gallagher

William Powell as Jim Wade

Myrna Loy as Eleanor Packer

Leo Carrillo as Father Joe

Nat Pendleton as Spud

George Sidney as Poppa Rosen

Isabel Jewell as Annabelle

Muriel Evans as Tootsie Malone

Thomas E. Jackson as Asst. Dist. Atty. Richard Snow

Isabelle Keith as Miss Adams

Noel Madison as Manny Arnold

Jimmy Butler as Jim Wade as a Boy

Mickey Rooney as Blackie as a Boy

Shirley Ross as Singer in Cotton Club

Donald Haines as Young Spud (uncredited)

Frank Conroy as Blackie's Defense Attorney (uncredited)

Leonid Kinskey as Trotskyite Slapping Poppa Rosen

Oscar Apfel as Speaker of Assembly (uncredited)

William Bailey as Al Barnes (uncredited)

Curtis Benton as Announcer (uncredited)

John Bleifer as Chauffeur (uncredited)

James Curtis as Party Leader (uncredited)

Vernon Dent as Otto (uncredited)

Charles Dunbar as Panhandler (uncredited)

Jay Eaton as Drunk (uncredited)

Wesley Giraud as Tough Boy (uncredited)

John Marston as Mr. Coates (uncredited)

Jack 'Tiny' Lipson as Uncle Angus (uncredited)

Leo Lance as Leon Trotsky (uncredited)

Pat Moriarity as Trotsky Heckler (uncredited)

William Arnold as Blackjack Dealer (uncredited)

Lew Harvey as Craps Dealer (uncredited)

Jimmy James as Chemin de Fer Dealer

Samuel S. Hinds as Warden of Sing Sing (uncredited)

Wade Boteler as Prison Guard (uncredited)

Sam McDaniel as Black Prisoner on Death Row (uncredited)

G. Pat Collins as Killer in Prison (uncredited)

James Eagles as Boy in Prison (uncredited)

Cullen Johnson as Boy (uncredited)

Payne B. Johnson as Small Boy on Street (uncredited)

Dixie Lotten as Irish Woman Talking with Poppa Rosen (uncredited)

Larry McGrath as One of Blackie's Hoods (uncredited)

Alex Melesh as Master of Ceremonies (uncredited)

Charles R. Moore as Black Man in Speakeasy (uncredited)

Don Brodie as Reporter (uncredited)

Ralph McCullough as Reporter (uncredited)

Eddie Hart as Reporter (uncredited)

George Irving as Jim's Campaign Manager (uncredited)

Leslie Preston as Jim's Dance Partner (uncredited)

Harrison Greene as Eleanor's Dance Partner (uncredited)

Bert Russell as Blind Beggar (uncredited)

Harry Seymour as Piano Player in Casino (uncredited)

Pepi Sinoff as Jewish Woman (uncredited)

Pete Smith as Racetrack Announcer (Voice) (uncredited)

Al Thompson as Street Spectator (uncredited)

Edward Van Sloan as Yacht Captain Swenson (uncredited)

Dorothy Vernon as Boat Passenger (uncredited)

Mary Gordon as Boat Passenger (uncredited)

William Irving as German Note Holder (uncredited)

Bert Sprotte as German Note Holder (uncredited)

William Stack as Judge (uncredited)

Lee Phelps as Bailiff (uncredited)

Landers Stevens as Inspector (uncredited)

William Augustin as Detective (uncredited)

Stanley Blystone as Detective in Court (uncredited)

Tom McGuire as Policeman in Court (uncredited)

Jack Kenney as Policeman (uncredited)

Lee Shumway as Policeman (uncredited)

Stanley Taylor as Police Intern (uncredited)

Sherry Hall as Assistant District Attorney (uncredited)

Emmett Vogan as Assistant District Attorney (uncredited)

King Mojave as Croupier (uncredited)

W.R. Walsh as Croupier (uncredited)