Lily-Rose Depp as Colleen Collette

Harley Quinn Smith as Colleen McKenzie

Natasha Lyonne as Tabitha

Adam Brody as Ichabod

Vanessa Paradis as Ms. Maurice

Ashley Greene as 'Peg Mom

Justin Long as Yogi Bayer

Ralph Garman as Old Man Arcane

Austin Butler as Hunter Calloway

Tony Hale as Bob Collette

Haley Joel Osment as Adrien Arcand

Jack Depp as 'Peg Son

Tyler Posey as Gordon Greenleaf

Genesis Rodriguez as Ms. Wicklund

Johnny Depp as Guy Lapointe

Kevin Smith as The Bratzis

Stan Lee as Dispatcher

Jennifer Schwalbach Smith as Mrs. McKenzie

Kevin Conroy as Canadian Bat, Man!

Jason Mewes as Rogue Cop

Harley Morenstein as Toilet Paper Man

Sasheer Zamata as Principal Invincible

Joel Shock as German Soldier (uncredited)

Christopher Drake as Disgruntled Eh-2-Zed Customer (uncredited)