John Michael Higgins as David Letterman

Daniel Roebuck as Jay Leno

Kathy Bates as Helen Kushnick

Bob Balaban as Warren Littlefield

Ed Begley Jr. as Rod Perth

Peter Jurasik as Howard Stringer

Reni Santoni as John Agoglia

John Kapelos as Robert Morton

Steven Gilborn as Peter Lassally

John Getz as Brandon Tartikoff

Lawrence Pressman as Bob Wright

Sandra Bernhard as Sandra Bernhard

Treat Williams as Michael Ovitz

David Brisbin as Alan Levine

Michael Chieffo as Rick Ludwin

Wendy Cutler as Reporter #2 Letterman Press Conference

Nancy Cheryll Davis as Reporter #2 Carnegie Hall

Paul Elder as Rupert Murdoch

Michael Fairman as Michael Gartner

John R. Fors as Writer #2

Nicholas Guest as Robert Iger

Lucinda Jenney as Debbie Vickers

Ivan Kane as Reporter #1

Ken Kragen as Ken Kragen

Susan Krebs as Airport Attendant

James Kiriyama-Lem as Reporter #1 Letterman Press Conference

Dan Lipe as Writer #1

Aaron Lustig as Paul Shaffer

Cynthia Lynch as Laurie Diamond

Michael C. McCarthy as Jim Brogan

Kerry Noonan as Letterman's Girlfriend

Penny Peyser as Susan Binford

Little Richard as Little Richard

Ann Ryerson as Betty Hudson

Kevin Scannell as Dick Ebersol

Edmund L. Shaff as Jack Welsh

Joanne Takahashi as Thai Waitress

Arthur Taxier as Lee Gabler

Cathy Worthington as Kragen's Asst.

Rich Little as Johnny Carson

Arnold F. Turner as Reporter #3 Letterman Press Conference

Dean Francois as CBS Executive to Howard Stringer (uncredited)

Angie Gray as Mrs. Wright (uncredited)