John Hurt as Dr. Joe Buchanan / Narrator (voice)

Raúl Juliá as Dr. Victor Frankenstein

Nick Brimble as The Monster

Bridget Fonda as Mary Wollstonecraft Godwin

Jason Patric as Lord George Gordon Byron

Michael Hutchence as Percy Byshee Shelley

Catherine Rabett as Elizabeth Lavenza

Catherine Corman as Justine Moritz

William Geiger as Lab Technician

Mickey Knox as General Reade

Myriam Cyr as Information Officer

Terri Treas as Buchanan's Car (voice)

Cynthia Allison as Newswoman

Isabella Rocchietta as Dorrie

John Karlsen as Parson

Donald Hodson as Old Man