David Harbour as David Harbour III / David Harbour Jr. / Frankenstein

Kate Berlant as Monica Fulton / Miss Machbeth

Alex Ozerov-Meyer as Joey Vallejo / Sal

Alfred Molina as Aubrey Fields / Captain

Michael Lerner as Bobby Fox

Mary Woronov as Nancy Erlich

Marion Van Cuyck as Niece

Lidia Porto as Detective Cepeda

Randolph Thompson as Mr. Orlando

Bridey Elliott as Reporter

O-Lan Jones as Mother

Heather Lawless as Doctor

Graham Wagner as Graham

Marc Vietor as Voice Over (voice)