Bill Murray as Don Johnston

Sharon Stone as Laura

Jessica Lange as Carmen

Tilda Swinton as Penny

Frances Conroy as Dora

Alexis Dziena as Lolita

Chloë Sevigny as Carmen's Assistant

Christopher McDonald as Ron

Julie Delpy as Sherry

Jeffrey Wright as Winston

Heather Simms as Mona

Chris Bauer as Dan

Larry Fessenden as Will

Brea Frazier as Rita

Jarry Fall as Winston and Mona's Kid

Korka Fall as Winston and Mona's Kid

Saul Holland as Winston and Mona's Kid

Zakira Holland as Winston and Mona's Kid

Niles Lee Wilson as Winston and Mona's Kid

Meredith Patterson as Flight Attendant

Jennifer Rapp as Girl on Bus

Nicole Abisinio as Girl on Bus

Ryan Donowho as Young Man on Bus

Dared Wright as Rabbit Owner

Suzanne Hevner as Mrs. Dorston

Brain McPeck as Guy in S.U.V.

Matthew McAuley as Guy in S.U.V.

Pell James as Sun Green

Mark Webber as The Kid

Homer Murray as Kid in Car

Rachel Puchkoff as Girl in House (uncredited) (unconfirmed)