Jeremy Brett as Sherlock Holmes

Edward Hardwicke as Dr. John Watson

Robert Hardy as Charles Augustus Milverton

Norma West as Lady Diana Swinstead

Gwen Ffrangcon Davies as The dowager

Colin Jeavons as Inspector Lestrade

Serena Gordon as Lady Eva Blackwell

Rosalie Williams as Mrs Hudson

Sophie Thompson as Agatha

Nickolas Grace as Bertrand

Sarah McVicar as The Hon. Charlotte Miles

David Mallinson as Colonel Dorking

Brian Mitchell as Harry, Earl of Dovercourt

Hans Meyer as Hebworth (Alias Veitch)

Stephen Simms as Stokes

Belinda Peters as Lillie

Henrietta Whitsun-Jones as Daphne

Alan Rothwell as Tronson, The Butler

Howard Gaye as Lewis, Dorking's Batman

David Scase as Art Gallery Owner

Jimmy Hibbert as Hobbs, The Painter

Tony Broughton as Auctioneer

Lee Clarke as Emile

Simon Fogg as Cabaret Artiste