Jessica Alba as Morley Clarkson

Kathy Bates as Susan Milton

Jessica Biel as Kara Monahan

Bradley Cooper as Holden Wilson

Eric Dane as Sean Jackson

Patrick Dempsey as Dr. Harrison Copeland

Héctor Elizondo as Edgar Paddington

Jamie Foxx as Kelvin Moore

Jennifer Garner as Julia Fitzpatrick

Topher Grace as Jason Morris

Anne Hathaway as Liz Curran

Carter Jenkins as Alex Franklin

Ashton Kutcher as Reed Bennett

Queen Latifah as Paula Thomas

Taylor Lautner as Willy Harrington

George Lopez as Alphonso Rodriguez

Shirley MacLaine as Estelle Paddington

Emma Roberts as Grace Smart

Julia Roberts as Captain Kate Hazeltine

Bryce Robinson as Edison

Taylor Swift as Felicia Miller

Katherine LaNasa as Pamela Copeland

Alexis Kendra as Friend Dana

Aramis Knight as (uncredited)

Larry Miller as Oversized Baggage Agent

Matthew Walker as Greg Gilkins

Beth Kennedy as Mrs. Claudia Smart

Kristen Schaal as Ms. Gilroy

Erin Matthews as Flight Attendant

Christine Lakin as Heather

Lauren Reeder as Hotel Clerk Michelle

Julia Springer as Olivia Copeland

Kathleen Marshall as Nikki

Anna Kulinova as Bulgarian Girl

Cassie Rowell as Coffee Barista

Faline England as Flower Shop Customer #1

James F. McCann as Flower Shop Customer #2

Shea Curry as Friend Elise

Wedil David as Rani's Mom Rehka

Natalie Machado as Indian Bride

Jennifer Leigh Warren as Party Singer

Megan Suri as Rani

Brooklynn Proulx as Madison

Karolinah Villarreal as Gwen

Joey Sorge as Amos

Alec Nemser as Charlie

Rick Batalla as Michael

Scott Crumly as Indian Restaurant Valet

Jonathan Morgan Heit as Tough Franklin

Angelo Salvatore Restaino as Alex's Friend Gideon

Scott Marshall as Mr. Schwabbe

Kelly Flynn as Referee

Sam Marshall as Soccer Son

Mandy Medlin as Teacher

Larrs Jackson as Chauffer Redmond

Cleo King as TSA Supervisor Daisy Bell

Corena Chase as TSA Security Officer

Justin Michael Duval as TSA Security Guard

Heidi Brucker as Southwest Gate Agent

Lily Marshall-Fricker as Lily

Kamilla Bjorlin as Sherry Donaldson

Anna A. White as Weather Girl

Stefanie Sherk as Stage Manager

Marty Nadler as Cameraman #1

Scott Sener as Cameraman #2

Colin Owens as Male Anchor

Calvin Jung as Flower Mart Simon

Serena Poon as Chinese Vendor

Kazumi Nakamura as Japanese Vendor

Gwenda Perez as Spanish Vendor

Kiko Kiko as Dodger Grandmother

Joseph Leo Bwarie as Mailroom Danny

Robert Belushi as Mailroom Ted

Jaclyn Miller as ACM Receptionist

Joe Smith as ACM Restaurant Waiter

Katie Joy Horwitch as ACM Outdoor Café Waitress

Lisa Roberts Gillan as Young Nurse

Barbara Marshall as Head Nurse

Stephanie Fabian as Candy Striper

Sandra Taylor as Beach Girl Candy

Sarah Lilly as Lady With Dog

Tony Scruggs as Beverly Wilshire Waiter

Roberta Valderrama as Angry Girlfriend

Cyrus Alexander as Cisco the Cheater

Paul Vogt as Shouting Sheldon

Bonnie Aarons as Strange Lady

Adreana Gonzalez as Cemetery Ticket Vendor

Matt Merchant as Loud Guy

Lisa Valenzuela as Loud Lady

Howard Storm as Louder Guy

Jennifer Amy as Bistro Gardens Waitress

Rance Howard as Bistro Gardens Diner

Travina Springer as Sign Language Interpreter

Tracy Reiner as French Photographer

Hannah Storm as ESPN Hannah Storm

Mike Greenberg as ESPN Radio Announcer #1 (voice)

Mike Golic as ESPN Radio Announcer #2 (voice)

Paul Williams as Romeo Midnight (voice)

Susie Abraham as Bridesmaid (uncredited)

Guilford Adams as Vista Movie Theatre Owner (uncredited)

Emily Arlook as Skater Girl (uncredited)

Lauren C. Brooks as Airport Customer (uncredited)

Jennifer De Minco as Cheerleader (uncredited)

Norman Deesing as Celebrity Lookalike (uncredited)

Vivi Devereaux as Waiter (uncredited)

Barbra Dunn as Restaurant Patron (uncredited)

Jerald Garner as Kara's Friend / Singer / Dancer (uncredited)

Roger Groh as Box Office Manager (uncredited)

Aimee Adams Hall as Rani's Friend (uncredited)

Cary Huff as Boyfriend on movie date (uncredited)

Rowan Joseph as Angry Soccer Dad (uncredited)

Kathryn Le as Connie (uncredited)

Hans Marrero as Gardner (uncredited)

Garry Marshall as Musician (uncredited)

Joe Mantegna as Angry Driver (uncredited)

Kristin Mellian as Bistro Gardens Waitress #2 (uncredited)

Angie Patterson as Nanny (uncredited)

Gladys Khan as Indian Groom Ajay's Mother (uncredited)

Mobin Khan as Indian Groom Ajay's Father (uncredited)

Taylor McCluskey as (uncredited)

Ash McNair as Wedding Guest (uncredited)

Aaron Pushkar as Bistro Gardens Bartender (uncredited)

Johnny Sale as Cougar's Date (uncredited)

Derek Theler as Masseur (uncredited)

Emily Moss Wilson as Kissing Girl (uncredited)

Greg Wilson as Kissing Guy (uncredited)

Joel Zaldivar as Beach Lover Boyfriend (uncredited)

Peter Allen Vogt as Cupid

Agnes-Nicole Winter as Theater Patron (uncredited)