Hilary Swank as Claire Morgan

Robert De Niro as Stan Harris

Michelle Pfeiffer as Ingrid Withers

Josh Duhamel as Sam

Sarah Jessica Parker as Kim Doyle

Zac Efron as Paul

Lea Michele as Elise

Ashton Kutcher as Randy

Halle Berry as Nurse Aimee

Jon Bon Jovi as Daniel Jensen

Katherine Heigl as Laura Carrington

Seth Meyers as Griffin Byrne

Jessica Biel as Tess Byrne

Til Schweiger as James Schwab

Carla Gugino as Spiritual Dr. Morriset

Cary Elwes as Stan's Doctor

Sofía Vergara as Ava

Héctor Elizondo as Kominsky

Abigail Breslin as Hailey Doyle

Ludacris as Brendan

Sarah Paulson as Grace Schwab

Alyssa Milano as Nurse Mindy

Jake T. Austin as Seth

Katherine McNamara as Lily Bowman

Nat Wolff as Walter

Yeardley Smith as Maude

Ryan Seacrest as Self

Michael Bloomberg as Self

Fiona Choi as Balinese Woman - Resolution Tour

Jim Belushi as Building Super

Mara Davi as Mika

Cassidy Reiff as Piper

Russell Peters as Chef Sunil

Serena Poon as Chef Ming

Common as Soldier

Jackie Seiden as Bride Trish

Joey McIntyre as Groom Rory

Beth Kennedy as Piper's Mom

Larry Miller as Harley (segment "Ahern Party")

Christine Lakin as Waitress Alyssa

Shea Curry as Wendy

Sandra Taylor as Patty

Matthew Broderick as Mr. Buellerton (uncredited)

John Lithgow as Jonathan Cox (uncredited)

Juliette Angelo as Sadie

Mary Marguerite Keane as Pet Adoption Clerk

Barbara Marshall as Head Nurse Helen

Lillian Lifflander as Mrs Lifflander

Penny Marshall as Penny Marshall

Cherry Jones as Mrs Rose Ahern

Charlotte Marshall-Fricker as Caring Teenage Girl (segment "Resolution Tour")

Michael Mandell as Murray (segment "Resolution Tour")

Patrick Reale as Times Square Cop (segment "Resolution Tour")