Snoop Dogg as Major LeGrande Bushe

Chase Masterson as Connie Garrison / Natasha

Dina Meyer as Female Moesha

Olivia d'Abo as Female Larrisha

Marina Sirtis as Award Show Presenter

Nana Visitor as Samantha Stamen

Michael Madsen as President Ben Dover

Jeffrey Combs as Male Larrisha

Michael Dorn as Real Robert Schmitt

Armin Shimerman as Male Moesha

Julie Warner as Female Curlisha

Nichelle Nichols as Sensei

Linda Park as Amber Earhardt

Gilbert Gottfried as LeGrande Bushe

Robert Picardo as Boris / Edgar Allan Putz

Walter Koenig as Fireman Frank

John Billingsley as Male Curlisha

Tim Russ as Unreal Robert Schmitt

Crystal Allen as Jasmine

Gary Graham as Neil Downe

Brenda Bakke as Christine Choppel

Celeste Yarnall as Celeste

Gary Lockwood as Gary

Manu Intiraymi as Durwood

Beverly Washburn as Beverly

Anthony Montgomery as Launchman

Vaughn Armstrong as Russell Sprout

Michael Forest as Self

BarBara Luna as Self

Kaley Victoria Rose as Laura Luzair

Brooke Newton as Ramora

Jasmine Jessica Anthony as Eileen Dover

Garrett Wang as Dr. Charles Hunter

Kevin Carlson as Captain Kirk Stillwood (voice)

Connor Trinneer as Captain Jack Youngblood

Angelique Fawcette as Lynn Hastings / Afro Agent / Nurse Uri / Don Gornelius Jr. / Nay Nay / Tay Tay / Cow / Dodo The 'Big Bang' Bean (voice)

Katarina van Derham as Captain Cheryl Stillwood

Dominic Keating as Hacky

Max Grodénchik as Paramedic Yacky

Casey Biggs as Detective Dan Marr

Patti Yasutake as Dr. Beverly Krasher

McKenzie Westmore as Self

Steve Rankin as Dr. Len McCoyy

Michael Dante as Michael Dante

Jack Donner as Jack Donner

Sean Kenney as Sean Kenney

Bobby Clark as Don Gornelius

Menina Fortunato as Rose

Christopher Doohan as Engineer Scootie Montgomery

Deprise Brescia as Daisy

Anne McDaniels as Anne Droid

Emily L. Stanton as Self

Guy Nardulli as Apollo

Steven Scot Bono as Buzz the Pothead

Peter Tedeschi as Budd The Pothead

Seth Austin as Harold the Herald

John Hafner as ATC Officer Roger Thompson

Brit Navarro as Tatty Tayle

Stevie Waichulis as Hammy The Hamster / Bystalker Flower (voice) (as Stephen Waichulis)

Sam Asghari as Self

Casper Smart as Self

Jeffrey Dinsdale as Film Set Security Guard

Mitch Alcala as Riley Finn

Angelique Kenney as Blonde Selfie Girl

Nadia Lanfranconi as Self

Royee Shen as Young Attendant #1

Vincent Shen as Young Attendant #2

Buster Pelster as Alien

Moses Castaneda as Alien

Bert Rotundo as Alien

Steven L. Fawcette as Captain Buttok Snortz (voice)