Tye Sheridan as Parzival / Wade

Olivia Cooke as Art3mis / Samantha

Ben Mendelsohn as Sorrento

Lena Waithe as Aech / Helen

T.J. Miller as I-R0k (voice)

Simon Pegg as Curator / Ogden Morrow

Mark Rylance as Anorak / Halliday

Philip Zhao as Sho

Win Morisaki as Daito

Hannah John-Kamen as F'Nale Zandor

Ralph Ineson as Rick

Susan Lynch as Alice

Clare Higgins as Mrs. Gilmore

Laurence Spellman as Lame Tattoo Guy (Reb)

Perdita Weeks as Kira

Joel MacCormack as Sixer #6655

Kit Connor as Reb Kid

Leo Heller as Reb Kid

Antonio Mattera as Reb Kid

Ronkẹ Adékoluẹjo as Sorrento's Assistant

William Gross as Ten-Year Old Kid

Gareth Mason as Chubby Guy

Sandra Dickinson as Old Boxing Woman

Lynne Wilmot as Pole Dancer

Jayden Fowora-Knight as Boy Playing Tennis

Gavin Marshall as Shift Manager / Mocap Core Cast

Mark Stanley as Old Zombie Woman

Emily Beacock as Twin

Rosanna Beacock as Twin

Gemma Refoufi as Pretty Naked Girl Body Double

Jane Leaney as Queen of Cats / Bathroom Zombie / Mocap Core Cast

Elliot Barnes-Worrell as Sixer #1

Asan N'Jie as Sixer #5 (Last Sixer)

Robert Gilbert as Andrew (Sorrento's Head of Security)

Stephen Mitchell as Police Officer

Letitia Wright as Reb (Safe House)

Kae Alexander as Reb (Safe House)

Joshua Archer as Mocap Core Cast / Sixer Instructor

Avye Leventis as Mocap Core Cast / Female Sixer #2

Dean Street as Mocap Core Cast

Michael Wildman as Sixer Drill Instructor

Turlough Convery as Chief Oology Expert

Joe Hurst as Oology Expert

Eric Sigmundsson as Oology Expert

James Dryden as Oology Expert

Danielle Phillips as Oology Expert

Rona Morison as Oology Expert

Khalil Madovi as Oology Expert

Bruce Lester-Johnson as IOI Board Member

Tom Turner as IOI Board Member

Paul Barnhill as Sorrento's Man

Isaac Andrews as Halliday 7 Years Old

Maeve Bluebell Wells as Female Sixer #1

Neet Mohan as Snacks (Bootsuit Commercial)

Georgie Farmer as Kid (Bootsuit Commercial)

Kathryn Wilder as Female Gamer (Bootsuit Commercial)

Sid Sagar as Regular Guy (Bootsuit Commercial)

David Forman as Hong Kong Businessman

Ian Davies as Police Officer (Stacks Explosion)

Lulu Wilson as Elementary Kid

Adolfo Álvarez as Elementary Kid

Alonso Alvarez as Elementary Kid

Jadah Marie as Elementary Kid

Dallas Dupree Young as Elementary Kid

Mckenna Grace as Elementary Kid

Arianna Jaffier as High School Kid

Armani Jackson as High School Kid

Britain Dalton as High School Kid

Jacob Bertrand as High School Kid

Daniel Zolghadri as High School Kid

Sydney Brower as Girl in Bedroom at House

Cara Pifko as Leslee

Vic Chao as Goro

Cara Theobold as Tracer

Daniel Eghan as Corporate Businessman (uncredited)

Julia Nickson as JN / Commuter (uncredited)

Kiera Bell as IOI Staff (uncredited)

Samantha Russell as Player (uncredited)

Violet McGraw as Shopping Cart Kid (uncredited)

Amy Clare Beales as Shop Staff (uncredited)

Racheal Ofori as Beautiful Woman (uncredited)

Jaeden Bettencourt as Soccer Player (uncredited)

Juan Carlos Cantu as Bus Passenger (uncredited)

Annarie Boor as Sixer (uncredited)

Mandy June Turpin as Actor (uncredited)