Tom Cruise as Barry Seal

Domhnall Gleeson as Monty 'Schafer'

Sarah Wright as Lucy Seal

Jesse Plemons as Sheriff Downing

Caleb Landry Jones as JB

Lola Kirke as Judy Downing

Jayma Mays as Dana Sibota

Alejandro Edda as Jorge Ochoa

Benito Martinez as James Rangel

E. Roger Mitchell as Agent Craig McCall

Jed Rees as Louis Finkle

Fredy Yate as Carlos Lehder

Mauricio Mejía as Pablo Escobar

Robert Farrior as Oliver North

Morgan Hinkleman as Christina

Alberto Ospino as Manuel Noriega

Felipe Bernedette as Translator

Daniel Lugo as Adolfo Calero

Jayson Warner Smith as Bill Cooper (Snowbird #1)

William Mark McCullough as Pete (Snowbird #2)

April Billingsley as Stewardess

Lauren Boyd as Secretary

Lauren Revard as Teller

Marcus Hester as Parka

Mike Pniewski as Willie (State Police)

Frank Licari as DEA Agent #1

Alex Collins as ATF #1

Scott Poythress as ATF #2

Connor Trinneer as George W. Bush / Texan

Alpha Trivette as Judge Linkletter

Kevin L. Johnson as Agent Horace Wainwright

DeVere Jehl as Plains Clothed Man

Emilio Sierra as Héctor (Colombian Driver)

Leon Lamar as Elderly Man

Tony Guerrero as Federico Vaughan

Maria Howell as NSC Woman

Darla Delgado as Customs Agent

Justice Leak as DEA Agent Winter

Robert Pralgo as Gary (Cubicle Mate)

Mickey Sumner as North's Aide Fawn Hall

Daniel Thomas May as CIA Man

Chloe Swan Sparwath as LeAnn

Alex Quarles as Aaron

Trip McCarthy as Dean

Zachary Powell as Dean

Daniel Diaz as Sandinista Soldier

Byron Wigfall as Contra #1

Matt Mercurio as FBI Analyst

Carlos Lopez Jr. as CIA Station Chief

Jairo Ordóñez as Scar

Jeff Olsen as State Trooper

Stephen Conroy as Military Police / Advisor

Juan Esteban Ramírez Toro as Antonio (Bull Fighter)

Lara Grice as Female Reporter (uncredited)

Sharon Conley as DEA Agent Grace (uncredited)

Chris Gann as Donor #2 (uncredited)

Johnny Otto as Pilot (uncredited)

Kayla Perkins as Waitress (uncredited)

Michael Mercaldi as Sandinista (uncredited)

Dan Southworth as Agent Winters (uncredited)

Bill Billions as Radar Op. #1 (uncredited)

Ronald Reagan as Self (archive footage) (uncredited)

Muhammad Ali as Self (archive footage) (uncredited)

Nancy Reagan as Self (archive footage) (uncredited)