Mark Feuerstein as Larry Gaye

Jayma Mays as April Elizabeth Farnekowski

Rebecca Romijn as Sally the Flightpal

Stanley Tucci as Publishing Executive

Henry Winkler as Stanley Warner

Danny Pudi as Nathan Vignes

Patrick Warburton as Captain Bryce

Jason Alexander as Larry's Dad

Molly Shannon as Emily McCoy

Leslie Coutterand as Isabella

Griffin Gluck as Donnie

Eric Stoltz as Russ Peterson

Jessica Lowndes as Suzanne

Christopher Fitzgerald as Curtis

Taye Diggs as Rasta Cab Driver

Molly Millard as Female Flight Attendant

Michael Cotter as Ash Man

Staci Roberts as Woman in 3B

Kenny Ellis as Rabbi

Guy Wilson as Frat Guy

Michael B. Silver as Charles Geddes

Adam Shapiro as Bob Techtronics

Ian Gomez as Captain Felder

Julie Hagerty as Elevator Flight Attendant

Marcia Gay Harden as President of the FAFAFA

Frank Gingerich as Young Larry

Allison Smith as Larry's Mom

Anthony Ruivivar as Flight School Administrator

Bob Gunton as Flight School Instructor

Pete Gardner as Flight School Doctor

Paul Zies as Beef Stew Guy

Bruno Oliver as Techtronics VP

Darius Devontaye Green as Taequan Black

John Yuan as Stuart Nevins

Matt Yuan as Johann Kaminsky

Samuel Gilbert as School Bully

Richard Riehle as Bartender

Byron McIntyre as Official

Kelly Donohue as BBQ Chicken Girl

Cean Houston as BBQ Chicken Guy

Jason Thompson as Lobster Man

Carlease Burke as LAX Ticket Agent

Frank Clem as Unaccompanied Miner

Howard Seth Cohen as Captain Gay

Jere Burns as Herb Thompkins

Rosanna Arquette as TV Anchorwoman

Steven Slater as Himself

Scott Hammer as Murphy Bed Repairman