Jack Nicholson as Henry Moon

Mary Steenburgen as Julia Tate

Christopher Lloyd as Towfield

John Belushi as Hector

Veronica Cartwright as Hermine

Richard Bradford as Sheriff Kyle

Jeff Morris as Big Abe

Danny DeVito as Hog

Tracey Walter as Coogan

Gerald H. Reynolds as Polty

Luana Anders as Mrs. Anderson

George W. Smith as Mr. Anderson

Lucy Lee Flippin as Mrs. Haber

Ed Begley Jr. as Mr. Haber

Maureen Byrnes as Mrs. Warren

B. J. Merholz as Mr. Warren

Britt Leach as Parson Weems

Georgia Schmidt as Florence

Barbara Ann Grimes as Spinster I

Anne Ramsey as Spinster II

Marsha Ferri as Spinster III

Lin Shaye as Parasol Lady

Don McGovern as Bartender

Dennis Fimple as Hangman

Annie Marshall as Painted Lady

Anita Terrian as Painted Lady

Robert Wilson as Drunk

Carlton Risdon as Stage Driver

Nancy Coan Kaclik as Mrs. Standard

R. L. Armstrong as Farmer Standard