Robert De Niro as Jack Byrnes

Ben Stiller as Greg Focker

Owen Wilson as Kevin Rawley

Dustin Hoffman as Bernie Focker

Barbra Streisand as Rozalin Focker

Blythe Danner as Dina Byrnes

Teri Polo as Pam Byrnes-Focker

Jessica Alba as Andi Garcia

Laura Dern as Prudence

Kevin Hart as Nurse Louis

Daisy Tahan as Samantha Focker

Colin Baiocchi as Henry Focker

Tom McCarthy as Dr. Bob

Harvey Keitel as Randy Weir

Yul Vazquez as Junior

Jack Axelrod as Chappy

Clent Bowers as Mr. Androvsky

Olga Fonda as Svetlana

Laksh Singh as Dr. Patel

Trula M. Marcus as Stage Producer

Jake Keiffer as Rufus

Rob Huebel as Sleazy Doctor

John DiMaggio as EMT

Jordan Peele as EMT

Kelli Kirkland as EMT

Deepak Chopra as Deepak Chopra

Robbie Tucker as EHS Tough Kid

Nick Kroll as Young Doctor

Sergio Calderón as Gustavo

Aaron Zachary Philips as Confused Child

David Pressman as Doctor

Hugh Dane as Doctor

Amy Stiller as Kristen

Richard Cotovsky as Newspaper Vendor

Trinity Warren as Climbing Kid

Samuel Schultz as Climbing Kid

Cade Rogers as Climbing Kid / Bounce House Kid

Ava Rose Williams as Climbing Kid

Frankie Torres as Climbing Kid

Kyla Warren as Party Kid

Erin Haisan as Party Kid

Ryder Bucaro as Party Kid

Callder Griffith as Party Kid

Lei'lah Star as Party Kid

David Williams as Party Kid

Randy Chuang as Monk

Joe Thamawat as Monk

Harry Bali as Sadu

Paul Herman as Caricature Artist

Leslie Garavito as Fire Pit Child

Cort Rogers as Bounce House Kid

Troy Lindsay Brown as Bounce House Kid

Erika Jensen as Party Parent

Robert Miano as Party Parent

Kat Kramer as Party Parent

Roy Jones Jr. as Party Parent

Derek Ressallat as Party Parent

Vladimir Kubr as Ballpit Kid

Semere-Ab Etmet Yohannes as Fire Walker

Nicole Pano as Art Teacher

Michael Naughton as Anatomy Professor

Celina Zambón as Carmencita

Shih Chou as Party Monk

Stan Egi as Man on Subway

Juan Antonio Bolivar as Flamenco Dancer

Michelle Castillo as Flamenco Dancer

Theo Crisell as Flamenco Dancer

Neisha Folkes-LeMelle as Flamenco Dancer

Jillana Laufer as Flamenco Dancer

Molly Rogers as Flamenco Dancer

Gary Sievers as Spanish Square Patron (uncredited)

Arnold Chon as Monk (uncredited)