Lucille Ball as Mame Dennis

Bea Arthur as Vera Charles

Robert Preston as Beauregard Jackson Pickett Burnside

Bruce Davison as Patrick as an adult

Kirby Furlong as Patrick as a boy

Jane Connell as Agnes Gooch

George Chiang as Ito

Joyce Van Patten as Sally Cato

Doria Cook-Nelson as Gloria Upson

Don Porter as Mr. Upson

Audrey Christie as Mrs. Upson

John McGiver as Mr. Babcock

Bobbi Jordan as Pegeen

Patrick Labyorteaux as Peter

Lucille Benson as Mother Burnside

Ruth McDevitt as Cousin Fan

Burt Mustin as Uncle Jeff

James Brodhead as Floorwalker

Leonard Stone as Stage Manager

Roger Price as Ralph Divine

John Wheeler as Judge Bregoff

Ned Wertimer as Fred Kates

Alice Nunn as Fat Lady

Jerry Ayres as Bunny

Michele Nichols as Midge

Eric Gordon as Boyd

Barbara Bosson as Emily

Don Ames as Party Guest (uncredited)

Robert Bakanic as Party Guest (uncredited)

Bobbie Bates as Dancer (uncredited)

Al Beaudine as Party Guest (uncredited)

Lois Berkson as Man (uncredited)

Gary Bohn as Bailiff (uncredited)

Richard Bolks as Dancer (uncredited)

Bart Carroll as Dancer (uncredited)

Patrick Cummings as Dancer (uncredited)

Fred Curt as Dancer (uncredited)

Randy Doney as Dancer (uncredited)

Gregory Drotar as Dancer (uncredited)

Ken DuMain as Party Guest (uncredited)

Brent Dunsford as Waiter (uncredited)

Peter Eastman as Theatre Patron (uncredited)

Eddie Garrett as Party Guest (uncredited)

Ken Grant as Dancer (uncredited)

Michael Gray as Dancer (uncredited)

Bob Harks as Commuter (uncredited)

Lars Hensen as Restaurant Patron (uncredited)

George Hickman as Restaurant Patron (uncredited)

George Holmes as Clerk (uncredited)

Bruce Hoy as Dancer (uncredited)

Casse Jaeger as Leading Man in Play (uncredited)

Kathryn Janssen as Theatre Patron (uncredited)

Sam Kwasman as Dancer (uncredited)

Joseph La Cava as Restaurant Patron (uncredited)

Mike Lally as Party Guest (uncredited)

Stan Mazin as Dancer (uncredited)

Rod McGaughy as Furniture Mover (uncredited)

Jim Michael as Bar Patron (uncredited)

Currie Pederson as Waiter / Dancer (uncredited)

Wanda Perry as Woman in Plaza Hotel (uncredited)

Frank Radcliffe as Party Guest (uncredited)

Leoda Richards as Theatre Patron (uncredited)

Victor Romito as Party Guest (uncredited)

Clark Ross as Party Guest (uncredited)

Alton Ruff as Dancer (uncredited)

Paul Russell as Party Guest (uncredited)

Jessie Salve as Bartender / Dancer (uncredited)

Jet Sharon as Dancer (uncredited)

George Simmons as Party Guest (uncredited)

Norman Stevans as Party Guest (uncredited)

Dean Taliaferro as Dancer (uncredited)

Tim Taylor as Dancer (uncredited)

Bob Templeton as Party Guest (uncredited)

Jerry Trent as Dancer (uncredited)

Judy Van Wormer as Dancer (uncredited)

Janice Whitby as Dancer (uncredited)

Marc Wilder as Dancer (uncredited)

Darcel Wynne as Dancer (uncredited)