Jennifer Aniston as Sandy

Julia Roberts as Miranda Collins

Kate Hudson as Jesse

Jason Sudeikis as Bradley

Sarah Chalke as Gabi

Britt Robertson as Kristin

Timothy Olyphant as Henry

Shay Mitchell as Tina

Jack Whitehall as Zack Zim

Margo Martindale as Flo

Robert Pine as Earl

Aasif Mandvi as Russell

Cameron Esposito as Max

Héctor Elizondo as Lance Wallace

Loni Love as Kimberly

Lucy Walsh as Jody

Beth Kennedy as Gwenda

Brandon Spink as Peter

Caleb Brown as Mikey

Ella Anderson as Vicky

Jessi Case as Rachel

Owen Vaccaro as Charlie

Jon Lovitz as Wally Burn

Anoush NeVart as Sonia

Jennifer Garner as Lt. Dana Barton

Gary Friedkin as Shorty

Matthew Walker as Randy the Clown

Lisa Roberts Gillan as Miranda's Assistant Betty

Adreana Gonzalez as Miranda's Publicist Inez

Grayson Russell as Tommy

Paul Vogt as Tiny

Penny Marshall as Opening Mom Narrator (voice)

Gianna Simone as Val

Ariana Neal as Evette

Sam Marshall as Peter's Friend Sam

Siena LaGambina as Paige

Joseph Leo Bwarie as Principal Bobby Lee

Brittany Belt as Beth Anne

Drew Matthews as Beanzie

Ayden Bivek as Tanner

Tom Hines as Club Announcer Brady

Rory O'Malley as Customer at Book Signing (Rory Schroder)

Sandra Taylor as Lexi

Tracey Bonner as Grocery Checker

Christine Lakin as Hostess

Inder Kumar as Bar Patron

Kevin Blake as Male Soccer Referee

Nicolette Noble as Comedy Audience Couple

Rob Nagle as Hotel Bellman

Hazel Moder as Cartwheel Kid

Kate Linder as Dog Walker Gigi

Wedil David as Dog Walker Leah

Larry Miller as Motorcycle Cop

Sean O'Bryan as Male Cop

Donielle Artese as Female Cop