Robert De Niro as Jackie Burke

Leslie Mann as Harmony Schiltz

Danny DeVito as Jimmy Berkowitz

Edie Falco as Miller

Harvey Keitel as Mac Schiltz

Charles Grodin as Dick D'Angelo

Patti LuPone as Florence Berkowitz

Cloris Leachman as May Conner

Veronica Ferres as Karola

Lois Smith as Miriam

Billy Crystal as Billy Crystal

Lucy DeVito as Brittany Berkowitz

Jim Norton as Jim Norton

Jimmie Walker as Jimmie Walker

Brett Butler as Brett Butler

Jessica Kirson as Jessica Kirson

Freddie Roman as Freddie Roman

Stewie Stone as Stewie Stone

Gilbert Gottfried as Gilbert Gottfried

Greer Barnes as Greer Barnes

Hannibal Buress as Hannibal Buress

Bill Boggs as Bill Boggs

Sheng Wang as Sheng Wang

Ryan Hamilton as Ryan Hamilton

Aida Rodríguez as Aida Rodriguez

Dov Davidoff as Dov Davidoff

Nick Di Paolo as Nick Di Paolo

Rebecca Kling as Heckler's Girlfriend

Jack Ricardo Miller as Homeless Man

Estee Adoram as Comedy Cellar Manager (uncredited)

Brooke Alexandra as Wedding Party (uncredited)

Happy Anderson as Heckler / Severin (uncredited)

Mark Axelowitz as Bartender at Friars Club (uncredited)

Aaron Ayhan as Lawyer (uncredited)

Marc Bicking as Spark's Maitre d' (uncredited)

Michael Birnberg as Steakhouse Customer (uncredited)

Susan Blackwell as Arlene (uncredited)

Marylouise Burke as Adele (uncredited)

José Báez as Homeless (uncredited)

Craig 'Radio Man' Castaldo as Soup kitchen - patron 1 (uncredited)

Lyman Chen as Chinese Waiter (uncredited)

Teddy Coluca as Fan (uncredited)

Stephanie Corbett as Bayou Babe (uncredited)

Savvy Crawford as The kid (uncredited)

Ray Crisara as Gary (uncredited)

Barbara Danicka as Stenographer (uncredited)

Barbara Ann Davison as Fan at Convention (uncredited)

Karin de la Penha as Woman on Train (uncredited)

Kevin Dohrenwend as Prison Inmate (uncredited)

Michael-Scott Druckenmiller as Floridian Parent (uncredited)

Sarah Fearon as Friars Club Member (uncredited)

Michael Fischetti as Older man (uncredited)

Abigail Friend as Wedding Guest (uncredited)

Bill Walters as Homeless in Soup Line (uncredited)

Richard Belzer as Himself