Dwayne Johnson as Frank Wolff

Emily Blunt as Dr. Lily Houghton

Edgar Ramírez as Lope de Aguirre

Jack Whitehall as McGregor Houghton

Jesse Plemons as Prince Joachim

Paul Giamatti as Nilo

Veronica Falcón as Trader Sam

Dani Rovira as Sancho

Quim Gutiérrez as Melchor

Dan Dargan Carter as Gonzalo

Andy Nyman as Sir James Hobbs-Coddington

Raphael Alejandro as Zaqueu

Simone Lockhart as Anna

Pedro Lopez as Chief

Sulem Calderon as Quila

Sebastian Blunt as Society Guard

Mark Ashworth as Society Member 1

Allan Poppleton as Society Worker

Caroline Paige as Kid Tourist

James Quattrochi as Italian Tourist

Stephen Dunlevy as Middlepart

Philipp Maximilian as Axel

Romualdo Castillo as Animal Vendor

Pedro Haro as Bird Vendor

Christina Souza as Barmaid

Michael H. Cole as Bus Conductor

Hector Banos as Puka Michuna Warrior

Peter Luis Zimmerman as Puka Michuna Warrior

Travis Gomez as Puka Michuna Warrior

David Lengel as Boat Tourist

Justin Randell Brooke as Boat Tourist

Piper Collins as Boat Tourist

Keith Arthur Bolden as Boat Tourist

Marcus Young as Goon (uncredited)

Tanya Wheelock as Boat Tourist (uncredited)

Robert Tinsley as London Guard (uncredited)