Will Ferrell as Megamind (voice)

Tina Fey as Roxanne Ritchi (voice)

Jonah Hill as Hal Stewart / Titan (voice)

Brad Pitt as Metro Man (voice)

David Cross as Minion (voice)

Justin Theroux as Megaminds's Father (voice)

Ben Stiller as Bernard (voice)

Jessica Schulte as Megamind's Mother (voice)

Tom McGrath as Lord Scott / Prison Guard (voice)

J.K. Simmons as Warden (voice)

Emily Nordwind as Lady Scott (voice)

Quinn Dempsey Stiller as Schoolchild (voice)

Ella Stiller as Schoolchild (voice)

Brian Hopkins as Prisoner (voice)

Christopher Knights as Prison Guard (voice)

Mike Mitchell as Father in Crowd (voice)

Jack Blessing as Newscaster (voice)

Jasper Johannes Andrews as Crying Baby (voice)

Stephen Kearin as Mayor (voice)

Rob Corddry as Metro City Citizen (uncredited)