Will Ferrell as Megamind (voice)

Brad Pitt as Metro Man (voice)

Tina Fey as Roxanne Ritchi (voice)

Jonah Hill as Tighten (voice)

David Cross as Minion (voice)

Ben Stiller as Bernard (voice)

Justin Theroux as Megaminds's Father (voice)

Jessica Schulte as Megamind's Mother (voice)

Tom McGrath as Lord Scott / Prison Guard (voice)

Emily Nordwind as Lady Scott (voice)

J.K. Simmons as Warden (voice)

Ella Stiller as Schoolchild (voice)

Quinn Dempsey Stiller as Schoolchild (voice)

Brian Hopkins as Prisoner (voice)

Christopher Knights as Prison Guard (voice)

Mike Mitchell as Father in Crowd (voice)

Jasper Johannes Andrews as Crying Baby (voice)

Jack Blessing as Newscaster (voice)

Stephen Kearin as Mayor (voice)