Rosa Salazar as Alita

Christoph Waltz as Dr. Dyson Ido

Jennifer Connelly as Chiren

Mahershala Ali as Vector

Ed Skrein as Zapan

Jackie Earle Haley as Grewishka

Keean Johnson as Hugo

Lana Condor as Koyomi

Jorge Lendeborg Jr. as Tanji

Eiza González as Nyssiana

Jeff Fahey as McTeague

Idara Victor as Nurse Gerhad

Rick Yune as Master Clive Lee

Derek Mears as Romo

Leonard Wu as Kinuba

Racer Rodriguez as Claymore

Marko Zaror as Ajakutty

Hugo Perez as Jacked Cyborg

Casper Van Dien as Amok

Billy Blair as Zapan's Cronie #1

Jamie Landau as Zapan's Cronie #2

Dimitrius Pulido as Cyborg Jacking Victim

Patrick Gathron as Antioch

Elle LaMont as Screwhead

Alex Livinalli as Blue Wingman

Neal Kodinsky as Red Wingman

Anthony Bandmann as Mace

Alan Trong as Kumaza

Sam Medina as Stinger

Tod Junker as Exploder

John Wirt as Cyborg Factory Worker

Darcel Danielle as Young Factory Worker

Emma Lindsey as Ido's Daughter

Garrett Warren as Barkeep

Tony LaThanh as Hunter Warrior #1

Jorge A. Jimenez as Hunter Warrior #2

Vincent Fuentes as Ed

Ibrahima Thiam as Guitarist

Paul de Sousa as Heckler

Gregg Berger as Deckman

David Sobolov as Centurion (voice)

Jeff Bottoms as Motorball Announcer (voice)

Michelle Rodriguez as Gelda (uncredited)

Jai Courtney as Jashugan (uncredited)

Edward Norton as Nova (uncredited)

Michael Love Toliver as Resident (uncredited)

Marcus J. Parker as Vector Guard (uncredited)

Evan King as Iron City Resident (uncredited)