David Harbour as Hellboy / Anung Un Rama

Milla Jovovich as Vivienne Nimue, the Blood Queen

Ian McShane as Trevor "Broom" Bruttenholm

Sasha Lane as Alice Monaghan

Daniel Dae Kim as Ben Daimio

Thomas Haden Church as Lobster Johnson

Stephen Graham as Gruagach (voice)

Douglas Tait as Gruagach

Sophie Okonedo as Lady Hatton

Alistair Petrie as Lord Adam Glaren

Brian Gleeson as Merlin

Penelope Mitchell as Ganeida

Mark Stanley as Arthur

Emma Tate as Baba Yaga (voice)

Troy James as Baba Yaga

Mario de la Rosa as Esteban Ruiz / Camazotz

Ava Brennan as Alice's Mother

Anthony Delaney as Alice's Father

Atanas Srebrev as Agent Madison

Dawn Sherrer as Agent Strode

Markos Rounthwaite as Grigori Rasputin

Ilko Iliev as Professor Doctor Karl Ruprecht Kroenen

Joel Harlow as Von Krupt

Dimiter Banenkin as Leopold Kurtz

Vanessa Eichholz as Ilsa Hepstein

Nadya Keranova as Sister #1

Maria Tepavicharova as Sister #2

Ana Tabakova as Sister #3

Terry Randal as Priest

Christopher Mata as Referee

Michael Heath as Butler

Rick Warden as Dr. Edwin Carp

Nitin Ganatra as August Swain

Kristina Klebe as Leni Riefenstahl

Charles Shannon as Sgt. Whitman

Carl Hampe as Sir Malcom Frost

Tony van Silva as Abbot

Josh Finan as Novice

Jonathan Steele as Huntsman

Simon Feek as M-11 Operative

Jasmine Audoux-Prevot as Baby Alice

Meglena Karalambova as Leprous Hag #1

Anna Bankina as Leprous Hag #2

Rut Rafailova as Leprous Hag #3

Laila Morse as Mrs. Harker

Peter Oxley as Gunsmith

Nikolay Stanoev as Monk

Manal El-Feitury as Mother

Elizabeth Mehari Kahsai as Child in Parking Lot #1

Said Barry Abdulai as Child in Parking Lot #2

Katya Peneva as Sarah Bethany Hughes

Natasha Kaplinsky as Anchorwoman

Valentin Stojanov as Man #1

Victor Rangelov as Man #2

Vasil Tsvetkov as Man #3

Joshua Samuel Hector as Man #4

John Wolfe as Horse Knight (uncredited)