David Arquette as Dewey Riley

Neve Campbell as Sidney Prescott

Courteney Cox as Gale Weathers-Riley

Emma Roberts as Jill Roberts

Hayden Panettiere as Kirby Reed

Anthony Anderson as Deputy Perkins

Adam Brody as Deputy Hoss

Rory Culkin as Charlie Walker

Mary McDonnell as Kate Roberts

Marley Shelton as Deputy Judy Hicks

Alison Brie as Rebecca Walters

Marielle Jaffe as Olivia Morris

Nico Tortorella as Trevor Sheldon

Erik Knudsen as Robbie Mercer

Anna Paquin as Rachel

Kristen Bell as Chloe

Lucy Hale as Sherrie

Shenae Grimes-Beech as Trudie

Britt Robertson as Marnie Cooper

Aimee Teegarden as Jenny Randall

Roger L. Jackson as "The Voice"

Nancy O'Dell as TV Host

Justin Michael Brandt as Film Geek

Dane Farwell as Ghostface

Gordon Michaels as Deputy Jenkins

John Lepard as Mr. Baker

Kim Adams as Reporter #2

Devin Scillian as Reporter #3

Mark Aaron Buerkle as Dr. Orth

Julia Ho as Reporter #1

Alexander Punch as Cocky Student

Heather Graham as Casey (archive footage)

Glenda Lewis as Reporter #4

William Spencer as Reporter #5

Tim Doty as Reporter #6

Peter Carey as Reporter #7

Wes Craven as Coroner (uncredited)