Antonio Banderas as Puss in Boots (voice)

Salma Hayek Pinault as Kitty Softpaws (voice)

Zach Galifianakis as Humpty Dumpty (voice)

Billy Bob Thornton as Jack (voice)

Amy Sedaris as Jill (voice)

Constance Marie as Imelda (voice)

Mike Mitchell as Andy Beanstalk (voice)

Rich Dietl as Bounty Hunter (voice)

Guillermo del Toro as Comandante / Hombre del bigote (voice)

Conrad Vernon as Raoul / Soldier (voice)

Chris Miller as Little Boy Blue / Friar Miller / Prison Guard / Manuel / Rafael (voice)

Ryan Crego as Luis (voice)

Tom Wheeler as Bartender / Mean Boy / Wagon Driver / Hotel Owner / Rodrigo (voice)

Tom McGrath as Bar Thief (voice)

Bob Joles as Giuseppe (voice)

Latifa Ouaou as Crazy Woman / Mean Girl / Milk Lady / Little Boy (voice)

Jessica Schulte as Estella Maria (voice)

Bob Persichetti as Ohhh Cat (voice)

Nina Barry as Ivana / Charo (voice)