Richard Gere as Dr. Alan Stone

Peter Dinklage as Joseph

Walton Goggins as Leon

Bradley Whitford as Clyde

Charlotte Hope as Becky

Julianna Margulies as Ruth

Kevin Pollak as Dr. Orbus

James Monroe Iglehart as Benny

Stephen Root as Dr. Rogers

Jane Alexander as Dr. Abraham

Julian Acosta as Dr. Francisco

Danny Deferrari as Neil

Chris Bannow as Louis

Kathryn Leigh Scott as Victoria Rogers

Christina Scherer as Carolyn

Nancy Robinette as Mrs. Gabor

Ripley Sobo as Molly

Stina Kalman as Nurse

George Aloi as Mental Patient

Ava Gallucci as Shirley Stone

Shade Rupe as Mental Patient

Frankie Verroca as Schizophrenic Patient