Christopher Lee as Sherlock Holmes

Thorley Walters as Dr. Watson

Hans Söhnker as Moriarty

Hans Nielsen as Cooper

Senta Berger as Ellen

Ivan Desny as Paul

Wolfgang Lukschy as Peter

Leon Askin as Charles

Edith Schultze-Westrum as Mrs. Hudson

Bruno W. Pantel as Auctioneer

Heinrich Gies as Buyer

Bernard Lajarrige as French

Linda Sini as Prostitute

Roland Armontel as Physician

Max Strassberg as Johnny

Danièle Argence as Librarian

Franco Giacobini as Collector

Waldemar Frahm as Butler

Rena Horten as Emily